The tiger genome and comparative analysis with lion and snow leopard genomes (Nature communication, 02 May 2013)
The researchers including Theragen Etex, led by Korea formed the International Tiger Genomics Consortium created the world’s first map of the genome of tiger, lion, and snow leopard in public. Tigers and Felidae are the most common endangered animals.
In this study, Not only the World’s first Siberian & Korean tiger’s genome map is provided but also the genome sequence of White tiger, lion, and snow leopard is provided. Through a genomic comparison and analysis of Felidae, the evidence of their evolutionary adaption is found based on carnivorous traits and motor ability. An unusual mutation of snow leopard that is correlated with adaption to alpine region is found. The traits that determines the white lion fur mutant is revealed and it shows that tigers and cats are similar to the structure of the genome.
The five published genome sequences of a large Felidae animal species is allied to genetic factors that determine the phenotype of a very valuable source of information to reveal.
Minke whale genome and aquatic adaptation in cetaceans (Nature genetics, 18 June 2013)
Theragen Etex including Korean research groups performed a genome sequencing of three Minke whales, Fin whale, Bottlenose dolphin, finless porpoise for comparative analysis and genome diversity. Whales are the largest of the Earth species, such as mammals and land animals about 60 million years ago from ancestors adapted to maritime quarter, is estimated to be evolved.
In this study, the smell of minke whale receptors are reduced in the ocean compared with land animals is regressive and unnecessary sensory organs. Due to the number of proteins in response to stress, a lot of stress on the marine environment was adapted to determine the facts. In addition, when long dives by anaerobic glycolysis that accumulates a lot of lactic acids, there are many genes involved in regulating the serum concentration of salts so that the water and the blood pressure could be controlled.
The whale genome research is published as an academic value for the evolutionary study, and could explain the unusual physiological phenomenon. Therefore, it is expected to contribute to the human disease research.
Comprehensive genome – and transcriptome – wide analyses of mutations associated with microsatellite instability in Korean gastric cancers (Genome Research, 23 July 2013)
Microsatellite instability (MSI) is a critical mechanism that drives genetic aberrations in cancer. To identify the entire MS mutation, we performed the first comprehensive genome- and transcriptome-wide analyses of mutations associated with MSI in Korean gastric cancer cell lines and primary tissues. We identified 18,377 MS mutations of five or more repeat nucleotides in coding sequences and untranslated regions of genes, and discovered 139 individual genes whose expression was down-regulated in association with UTR MS mutation. In addition, we found that 90.5% of MS mutations with deletions in gene regions occurred in UTRs. This analysis emphasizes the genetic diversity of MSI-H gastric tumors and provides clues to the mechanistic basis of instability in microsatellite unstable gastric cancers.
This work was supported in part by the National Research Foundation of Korea (NRF) grants (2009-0081756 and 2012M3A9C4048736) and by the Korea Health Industry Development Institute (KHIDI; A090726). J.B. and S.L. were supported by TheragenEtex and Genome Research Foundation internal funds.
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